Endocrine Abstracts

A 65-year-old Caucasian gentleman was admitted with weight loss and generally feeling unwell. X ray chest done a week before admission as part of routine investigation by the General Practitioner, showed healing rib fractures with diffuse sclerosis. Malignancy was initially suspected due to the bony changes in the chest X-ray. Hence a full body CT scan was done and was normal. Incidentally he was noted to have low adjusted calcium of 2.16 mmol/l (2.20–2.60), raised parath...

Case history: 73-year-old male was seen in breast clinic for right breast lump which was noted 6 weeks back with no nipple discharge. Mammogram and ultrasound confirmed bilateral gynaecomastia more on right side. Referred to endocrine clinic with abnormal hormone profile. He is a retired builder. He was a heavy smoker for 50 years and has stopped smoking 1 year back. He drinks socially and has never used illicit drugs. His only past medical history was GORD for which he takes ...

A 64 year old lady was admitted with a 2 day history of feeling generally unwell. Her relatives also reported new onset confusion over these 2 days. Her bloods showed raised inflammatory markers (CRP 110.3 mg/l, WCC 18.2×109/l) hypoalbuminemia (17 g/l), bilirubinemia (55 μmol/l) and a raised alkaline phosphatase (917 IU/l). She had recently been diagnosed with carcinoid syndrome; primary tumour situated in the terminal ileum with liver metastasis and had b...

AKI is a potentially a life threatening condition and it is extremely crucial to investigate the root cause it order to manage the patient appropriately.Case reportA 30 years old female presented with complaints of generalized muscle weakness, lethargy and mood changes. She was found to have raised creatinine with significant drop in her GFR to 41. Rest of her electrolytes and full blood count were within normal range. She was comm...

BackgroundPembolizumab is a highly specific, monoclonal antibody directed against the programmed cell death receptor, PD-1 and its ligand PD-L1. It is licenced as an immunotherapy for use in locally advanced or metastatic urothelial cell carcinoma, amongst other malignancies. Whilst rare, endocrinopathies, including thyroid dysfunction, are recognised side effects of immunotherapy such as Pembroluzimab. However, hyperthyroidism is much less common than h...

Introduction: Hypokalaemic periodic paralysis is a medical emergency when patients present with acute onset paraparesis usually noticed in the mornings secondary to low serum potassium levels with a prevalence of 1 in100,000. The symptoms resolve promptly with correction of potassium. The patient experiences motor symptoms while the sensation is preserved and can be differentiated from acute inflammatory demyelinating polyneuropathy with preserved ocular, bulbar or respiratory...

Title – Testosterone replacement Therapy (TRT) and prostate cancer Hypogonadism is a condition with low serum testosterone level, which can manifest as depression, lack of libido, decreased bone mineral density and muscle weakness In patients with hypogonadism returning serum testosterone to normal levels results in improvement in cognition, mood, sexual function, physical performance, normalises bone density and erythropoiesis.Case<p class="abs...